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Awesome Bioinformatics
A curated list of awesome Bioinformatics libraries and software.
danielecook/Awesome-Bioinformatics
#awesome
#awesome-list
#bioinformatics
- List stars
- 4,329
- README repos
- 132
- Indexed repos
- 127
- List commits
- 273
- Forks
- 742
- Open issues
- 46
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Latest scan 2026-10-22 10:49
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biopython/biopython
Official git repository for Biopython (originally converted from CVS)
GitHub topics
- Updated
- 2026-10-22
- Lists
- 2 list mentions
- First commit
- 1999-12-08
- License
- NOASSERTION
- Issues
- 634 open
5,241
stars
- Forks
- 1,976
- Commits
- 16,369 commits
- Star growth, last 7 days
- +6 +0.1%
- Commit velocity, last 7 days
- +3 0.0%
google/deepvariant
DeepVariant is an analysis pipeline that uses a deep neural network to call genetic variants from next-generation DNA sequencing data.
GitHub topics
- Updated
- 2026-09-30
- Lists
- 1 list mention
- First commit
- 2017-12-01
- License
- BSD-3-Clause
- Issues
- 8 open
3,824
stars
- Forks
- 806
- Commits
- 3,378 commits
- Star growth, last 7 days
- 0 0.0%
- Commit velocity, last 7 days
- 0 0.0%
lh3/minimap2
A versatile pairwise aligner for genomic and spliced nucleotide sequences
GitHub topics
- Updated
- 2026-05-19
- Lists
- 1 list mention
- First commit
- 2017-04-05
- License
- NOASSERTION
- Issues
- 79 open
2,258
stars
- Forks
- 480
- Commits
- 1,224 commits
- Star growth, last 7 days
- 0 0.0%
- Commit velocity, last 7 days
- 0 0.0%
lh3/bwa
Burrow-Wheeler Aligner for short-read alignment (see minimap2 for long-read alignment)
Stack
GitHub topics
- Updated
- 2026-08-07
- Lists
- 1 list mention
- First commit
- 2011-01-14
- License
- GPL-3.0
- Issues
- 100 open
1,769
stars
- Forks
- 580
- Commits
- 1,000 commits
- Star growth, last 7 days
- 0 0.0%
- Commit velocity, last 7 days
- 0 0.0%
hail-is/hail
Cloud-native genomic dataframes and batch computing
AI dev
- Updated
- 2026-10-21
- Lists
- 1 list mention
- First commit
- 2015-07-24
- License
- MIT
- Issues
- 399 open
1,080
stars
- Forks
- 266
- Commits
- 12,281 commits
- Star growth, last 7 days
- 0 0.0%
- Commit velocity, last 7 days
- 0 0.0%
chhylp123/hifiasm
Hifiasm: a haplotype-resolved assembler for accurate Hifi reads
Stack
GitHub topics
- Updated
- 2026-05-31
- Lists
- 1 list mention
- First commit
- 2019-05-09
- License
- MIT
- Issues
- 622 open
818
stars
- Forks
- 133
- Commits
- 645 commits
- Star growth, last 7 days
- 0 0.0%
- Commit velocity, last 7 days
- 0 0.0%
BenLangmead/bowtie2
A fast and sensitive gapped read aligner
GitHub topics
- Updated
- 2026-09-22
- Lists
- 1 list mention
- First commit
- 2011-03-12
- License
- GPL-3.0
- Issues
- 197 open
811
stars
- Forks
- 180
- Commits
- 2,682 commits
- Star growth, last 7 days
- 0 0.0%
- Commit velocity, last 7 days
- 0 0.0%
vcflib/vcflib
C++ library and cmdline tools for parsing and manipulating VCF files with python and zig bindings
GitHub topics
- Updated
- 2026-10-02
- Lists
- 1 list mention
- First commit
- 2010-09-22
- License
- MIT
- Issues
- 17 open
687
stars
- Forks
- 223
- Commits
- 1,699 commits
- Star growth, last 7 days
- 0 0.0%
- Commit velocity, last 7 days
- 0 0.0%
biojava/biojava
:book::microscope::coffee: BioJava is an open-source project dedicated to providing a Java library for processing biological data.
GitHub topics
- Updated
- 2026-09-29
- Lists
- 1 list mention
- First commit
- 2009-09-15
- License
- LGPL-2.1
- Issues
- 70 open
634
stars
- Forks
- 400
- Commits
- 7,058 commits
- Star growth, last 7 days
- 0 0.0%
- Commit velocity, last 7 days
- 0 0.0%
mdshw5/pyfaidx
Efficient pythonic random access to fasta subsequences
- Updated
- 2026-10-21
- Lists
- 1 list mention
- First commit
- 2013-09-12
- License
- NOASSERTION
- Issues
- 3 open
489
stars
- Forks
- 80
- Commits
- 938 commits
- Star growth, last 7 days
- 0 0.0%
- Commit velocity, last 7 days
- 0 0.0%
GMOD/jbrowse
JBrowse 1, a full-featured genome browser built with JavaScript and HTML5. For JBrowse 2, see https://github.com/GMOD/jbrowse-components.
- Updated
- 2026-07-16
- Lists
- 1 list mention
- First commit
- 2007-06-18
- License
- NOASSERTION
- Issues
- 158 open
474
stars
- Forks
- 199
- Commits
- 8,175 commits
- Star growth, last 7 days
- 0 0.0%
- Commit velocity, last 7 days
- 0 0.0%
brentp/cyvcf2
cython + htslib == fast VCF and BCF processing
- Updated
- 2026-09-10
- Lists
- 1 list mention
- First commit
- 2015-08-12
- License
- MIT
- Issues
- 51 open
450
stars
- Forks
- 79
- Commits
- 552 commits
- Star growth, last 7 days
- 0 0.0%
- Commit velocity, last 7 days
- 0 0.0%
brentp/vcfanno
annotate a VCF with other VCFs/BEDs/tabixed files
Stack
GitHub topics
- Updated
- 2026-06-16
- Lists
- 1 list mention
- First commit
- 2015-04-24
- License
- MIT
- Issues
- 38 open
403
stars
- Forks
- 57
- Commits
- 380 commits
- Star growth, last 7 days
- 0 0.0%
- Commit velocity, last 7 days
- 0 0.0%
brentp/somalier
fast sample-swap and relatedness checks on BAMs/CRAMs/VCFs/GVCFs... "like damn that is one smart wine guy"
Stack
GitHub topics
- Updated
- 2026-10-20
- Lists
- 1 list mention
- First commit
- 2018-07-17
- License
- MIT
- Issues
- 64 open
341
stars
- Forks
- 50
- Commits
- 323 commits
- Star growth, last 7 days
- 0 0.0%
- Commit velocity, last 7 days
- 0 0.0%
luntergroup/octopus
Bayesian haplotype-based mutation calling
GitHub topics
- Updated
- 2026-02-13
- Lists
- 1 list mention
- First commit
- 2015-02-04
- License
- MIT
- Issues
- 65 open
327
stars
- Forks
- 37
- Commits
- 5,045 commits
- Star growth, last 7 days
- 0 0.0%
- Commit velocity, last 7 days
- 0 0.0%
lh3/wgsim
Reads simulator
Stack
GitHub topics
- Updated
- 2021-09-03
- Lists
- 1 list mention
- First commit
- 2011-01-22
- License
- Unknown
- Issues
- 21 open
290
stars
- Forks
- 92
- Commits
- 14 commits
- Star growth, last 7 days
- 0 0.0%
- Commit velocity, last 7 days
- 0 0.0%
brentp/smoove
structural variant calling and genotyping with existing tools, but, smoothly.
Stack
GitHub topics
- Updated
- 2024-06-17
- Lists
- 1 list mention
- First commit
- 2018-01-27
- License
- Apache-2.0
- Issues
- 101 open
267
stars
- Forks
- 22
- Commits
- 174 commits
- Star growth, last 7 days
- 0 0.0%
- Commit velocity, last 7 days
- 0 0.0%
biodatageeks/polars-bio
Blazing-Fast Bioinformatic Operations on Python DataFrames
AI dev
GitHub topics
- Updated
- 2026-10-21
- Lists
- 2 list mentions
- First commit
- 2024-11-26
- License
- Apache-2.0
- Issues
- 52 open
205
stars
- Forks
- 35
- Commits
- 302 commits
- Star growth, last 7 days
- 0 0.0%
- Commit velocity, last 7 days
- 0 0.0%
divonlan/genozip
A modern compressor for genomic files (FASTQ, SAM/BAM/CRAM, VCF, FASTA, GFF/GTF/GVF, 23andMe...), up to 5x better than gzip and faster too
- Updated
- 2026-10-19
- Lists
- 1 list mention
- First commit
- 2019-12-15
- License
- NOASSERTION
- Issues
- 0 open
191
stars
- Forks
- 14
- Commits
- 3,326 commits
- Star growth, last 7 days
- 0 0.0%
- Commit velocity, last 7 days
- 0 0.0%
telatin/seqfu2
:rocket: seqfu - Sequece Fastx Utilities
AI dev
GitHub topics
- Updated
- 2026-10-13
- Lists
- 1 list mention
- First commit
- 2020-11-26
- License
- GPL-3.0
- Issues
- 0 open
132
stars
- Forks
- 10
- Commits
- 785 commits
- Star growth, last 7 days
- 0 0.0%
- Commit velocity, last 7 days
- 0 0.0%
incertae-sedis/smof
Explore and analyze biological sequence data
GitHub topics
- Updated
- 2024-08-01
- Lists
- 1 list mention
- First commit
- 2014-04-27
- License
- MIT
- Issues
- 0 open
19
stars
- Forks
- 3
- Commits
- 583 commits
- Star growth, last 7 days
- 0 0.0%
- Commit velocity, last 7 days
- 0 0.0%